期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 17, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/ijms17101638
关键词
DNA damage responses; HIPK2; HP1 gamma; cell cycle; apoptosis
资金
- Japan Society for the Promotion of Science [26293169, 15K15294, 26713027]
- Grants-in-Aid for Scientific Research [15K15294, 15K08949, 26293169, 26713027] Funding Source: KAKEN
Homeodomain-interacting protein kinase 2 (HIPK2) is a serine/threonine kinase that phosphorylates and activates the apoptotic program through interaction with diverse downstream targets including tumor suppressor p53. HIPK2 is activated by genotoxic stimuli and modulates cell fate following DNA damage. The DNA damage response (DDR) is triggered by DNA lesions or chromatin alterations. The DDR regulates DNA repair, cell cycle checkpoint activation, and apoptosis to restore genome integrity and cellular homeostasis. Maintenance of the DDR is essential to prevent development of diseases caused by genomic instability, including cancer, defects of development, and neurodegenerative disorders. Recent studies reveal a novel HIPK2-mediated pathway for DDR through interaction with chromatin remodeling factor homeodomain protein 1 gamma. In this review, we will highlight the molecular mechanisms of HIPK2 and show its functions as a crucial DDR regulator.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据