4.2 Article Proceedings Paper

Efficacy of systemic diclofenac sodium on intravitreal concentration

期刊

INTERNATIONAL OPHTHALMOLOGY
卷 38, 期 1, 页码 99-104

出版社

SPRINGER
DOI: 10.1007/s10792-016-0428-8

关键词

Vitreous; Diclofenac; Nonsteroidal anti-inflammatory drugs; Slow release; Chemical injury

资金

  1. office of Vice-Chancellor for Research Affairs of Baqiyatallah University of Medical Sciences

向作者/读者索取更多资源

Background Nonsteroidal anti-inflammatory drugs (NSAIDs), as an alternative, are replacing corticosteroids in ocular inflammatory diseases. Diclofenac has been usedmainly topically, and recent focus has been on intravitreal delivery. Both of these methods have been shown to have complications in long-term application. Purpose To assess the efficacy of slow release oral diclofenac sodium on intravitreal concentration in experimental model of chemically injured eyes. Methods In an experimental double-masked clinical trial, right eyes of 24 albino rabbits were chemically injured by 1 N NaOH. One hour after chemical injury, 10 cc suspension gavage containing 100 mg slow release diclofenac sodium was administered in all cases. 2, 4, 6, 12, 24, 48 h after gavage, vitreous samples were obtained in all cases. Intravitreal concentration of diclofenac sodium was evaluated in all samples using high-performance liquid chromatography (HPLC) method. Results Intravitreal diclofenac levels by oral intake were enhanced by the inflammation in all the measurements. In inflamed eyes, diclofenac concentration was ten times more than control eye (2.658 +/- 0.344 vs. 0.242 +/- 0.0279 and 1.617 +/- 0.527 vs. 0.148 +/- 0.095; in 2 and 4 h, respectively). After 6 h, diclofenac concentration was statistically different, although it reduced below 1 mu g/ml. Conclusion Diclofenac is delivered to the inflamed eye more than healthy eye. It seems that by oral diclofenac consumption, it is possible to make a significant intravitreal concentration.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.2
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据