期刊
FRONTIERS IN IMMUNOLOGY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2017.00749
关键词
interferon-lambda; enteric virus; innate immunity; transkingdom interactions; norovirus; rotavirus; commensal bacteria
类别
资金
- Basic Science Research Program through the National Research Foundation of Korea - Ministry of Education [NRF-2016R1A6A3A03012352]
- National Institutes of Health (NIH) grant [K22 AI127846-01]
- DDRCC grant [P30 DK052574]
Interferon-lambda (IFN-lambda) is a recently described cytokine found to be of critical importance in innate immune regulation of intestinal viruses. Endogenous IFN-lambda. has potent antiviral effects and has been shown to control multiple intestinal viruses and may represent a factor that contributes to human variability in response to infection. Importantly, recombinant IFN-lambda has therapeutic potential against enteric viral infections, many of which lack other effective treatments. In this mini-review, we describe recent advances regarding IFN-lambda-mediated regulation of enteric viruses with important clinical relevance including rotavirus, reovirus, and norovirus. We also briefly discuss IFN-lambda interactions with other cytokines important in the intestine, and how IFN-lambda may play a role in regulation of intestinal viruses by the commensal microbiome. Finally, we indicate currently outstanding questions regarding IFN-lambda control of enteric infections that remain to be explored to enhance our understanding of this important immune molecule.
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