期刊
FRONTIERS IN IMMUNOLOGY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2017.00453
关键词
helminthic therapy; autoimmunity; immunomodulation; excretory/secretory products; immunotherapy
类别
资金
- Australian Postgraduate Award
- Australian Research Council Future Fellowship [FT100100476]
- Australian Infectious Disease Research Centre
- National Cancer Institute [R01CA155297]
- National Health and Medical Research (NHMRC) Senior Principle Research Fellowship [1117505]
- Advance Queensland Fellowship
- Career Development Fellowship [1031652, 1051627]
- Australian Research Council [FT100100476] Funding Source: Australian Research Council
Helminths have evolved to become experts at subverting immune surveillance. Through potent and persistent immune tempering, helminths can remain undetected in human tissues for decades. Redirecting the immunomodulating talents of helminths to treat inflammatory human diseases is receiving intensive interest. Here, we review therapies using live parasitic worms, worm secretions, and worm-derived synthetic molecules to treat autoimmune disease. We review helminth therapy in both mouse models and clinical trials and discuss what is known on mechanisms of action. We also highlight current progress in characterizing promising new immunomodulatory molecules found in excretory/secretory products of helminths and their potential use as immunotherapies for acute and chronic inflammatory diseases.
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