期刊
FRONTIERS IN IMMUNOLOGY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2017.01626
关键词
allogeneic; allo-mesenchymal stromal cell; anti-donor immune response; immunogeniciy; inflammation; immunomodulation
类别
资金
- Science Foundation Ireland [12/IA/1624]
- EU FP7 [Collaborative Health Project VISICORT] [602470]
- Science Foundation Ireland [REMEDI Strategic Research Cluster) [09/SRC-B1794]
- CURAM Research Centre [13/RC/2073]
- European Commission [Horizon Collaborative Health Project NEPHSTROM] [634086]
- European Regional Development Fund
- Irish Cancer Society Fellowship [CRF12RYA]
- Science Foundation Ireland Starting Investigator Grant [15/SIRG/3456]
- H2020 Societal Challenges Programme [634086] Funding Source: H2020 Societal Challenges Programme
Mesenchymal stromal cells (MSC) have been used to treat a broad range of disease indications such as acute and chronic inflammatory disorders, autoimmune diseases, and transplant rejection due to their potent immunosuppressive/anti-inflammatory properties. The breadth of their usage is due in no small part to the vast quantity of published studies showing their ability to modulate multiple immune cell types of both the innate and adaptive immune response. While patient-derived (autologous) MSC may be the safer choice in terms of avoiding unwanted immune responses, factors including donor comorbidities may preclude these cells from use. In these situations, allogeneic MSC derived from genetically unrelated individuals must be used. While allogeneic MSC were initially believed to be immune-privileged, substantial evidence now exists to prove otherwise with multiple studies documenting specific cellular and humoral immune responses against donor antigens following administration of these cells. In this article, we will review recent published studies using non-manipulated, inflammatory molecule-activated (licensed) and differentiated allogeneic MSC, as well as MSC extracellular vesicles focusing on the immune responses to these cells and whether or not such responses have an impact on allogeneic MSC-mediated safety and efficacy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据