期刊
FRONTIERS IN IMMUNOLOGY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2017.00622
关键词
human immunodeficiency virus reservoir; cytotoxic T lymphocytes; follicular helper T cells; T-FH reservoir; B cell follicle sanctuary
类别
资金
- National Health and Medical Research Council of Australia [GNT1085509]
- amfAR Research Consortium on HIV Eradication [10932759-RGRL]
- Creative and Novel Ideas in HIV Research Program of The International AIDS Society
- Australian Centre for HIV and Hepatitis Virology Research [2015-69]
Human immunodeficiency virus (HIV) infects millions of people worldwide, and new cases continue to emerge. Once infected, the virus cannot be cleared by the immune system and causes acquired immunodeficiency syndrome. Combination antiretroviral therapeutic regimen effectively suppresses viral replication and halts disease progression. The treatment, however, does not eliminate the virus-infected cells, and interruption of treatment inevitably leads to viral rebound. The rebound virus originates from a group of virus-infected cells referred to as the cellular reservoir of HIV. Identifying and eliminating the HIV reservoir will prevent viral rebound and cure HIV infection. In this review, we focus on a recently discovered HIV reservoir in a subset of CD4(+) T cells called the follicular helper T (T-FH) cells. We describe the potential mechanisms for the emergence of reservoir in TFH cells, and the strategies to target and eliminate this viral reservoir.
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