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FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation
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Mutations in Complement Factor H Impair Alternative Pathway Regulation on Mouse Glomerular Endothelial Cells in Vitro
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FHR3 Blocks C3d-Mediated Coactivation of Human B Cells
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JOURNAL OF IMMUNOLOGY (2016)
Factor H-Related Protein 5 Interacts with Pentraxin 3 and the Extracellular Matrix and Modulates Complement Activation
Adam I. Csincsi et al.
JOURNAL OF IMMUNOLOGY (2015)
Of mice and men: The factor H protein family and complement regulation
R. B. Pouw et al.
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Factor H-related proteins determine complement-activating surfaces
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Structural basis for sialic acid-mediated self-recognition by complement factor H
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Complement factor H related hybrid protein deregulates complement in dense deposit disease
Qian Chen et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
New insights into disease-specific absence of complement factor H related protein C in mouse models of spontaneous autoimmune diseases
Gaurav Mehta et al.
MOLECULAR IMMUNOLOGY (2014)
Competition between antagonistic complement factors for a single protein on N-meningitidis rules disease susceptibility
Joseph J. E. Caesar et al.
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Functional Anatomy of Complement Factor H
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BIOCHEMISTRY (2013)
C3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulation
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Tissue-Specific Host Recognition by Complement Factor H Is Mediated by Differential Activities of Its Glycosaminoglycan-Binding Regions
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Essential Role of Surface-Bound Complement Factor H in Controlling Immune Complex-Induced Arthritis
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Christine Skerka et al.
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Human Factor H-Related Protein 2 (CFHR2) Regulates Complement Activation
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Dimerization of complement factor H-related proteins modulates complement activation in vivo
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Factor H-related Protein 4 Activates Complement by Serving as a Platform for the Assembly of Alternative Pathway C3 Convertase via Its Interaction with C3b Protein
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JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Atypical Hemolytic Uremic Syndrome-Associated Variants and Autoantibodies Impair Binding of Factor H and Factor H-Related Protein 1 to Pentraxin 3
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Factor H: A Complement Regulator in Health and Disease, and a Mediator of Cellular Interactions
Anne Kopp et al.
BIOMOLECULES (2012)
Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury
Brandon Renner et al.
KIDNEY INTERNATIONAL (2011)
Structural basis for engagement by complement factor H of C3b on a self surface
Hugh P. Morgan et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)
Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Zebrafish complement factor H and its related genes: identification, evolution, and expression
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FUNCTIONAL & INTEGRATIVE GENOMICS (2010)
An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD)
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HUMAN MOLECULAR GENETICS (2010)
Factor H and Factor H-Related Protein 1 Bind to Human Neutrophils via Complement Receptor 3, Mediate Attachment to Candida albicans, and Enhance Neutrophil Antimicrobial Activity
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Molecular basis of C-reactive protein binding and modulation of complement activation by factor H-related protein 4
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Functional analyses indicate a pathogenic role of factor H autoantibodies in atypical haemolytic uraemic syndrome
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Factor H-related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formation
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Characterization of complement factor H-related (CFHR) proteins in plasma reveals novel genetic variations of CFHR1 associated with atypical hemolytic uremic syndrome
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BLOOD (2009)
Monomeric CRP contributes to complement control in fluid phase and on cellular surfaces and increases phagocytosis by recruiting factor H
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Human complement factor H-related protein 4 binds and recruits native pentameric C-reactive protein to necrotic cells
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The spectrum of phenotypes caused by variants in the CFH gene
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A new map of glycosaminoglycan and C3b binding sites on factor H
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Properdin binds to late apoptotic and necrotic cells independently of C3b and regulates alternative pathway complement activation
Wei Xu et al.
JOURNAL OF IMMUNOLOGY (2008)
C4b-binding protein and factor h compensate for the loss of membrane-bound complement inhibitors to protect apoptotic cells against excessive complement attack
Leendert A. Trouw et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Anti-factor H autoantibodies block C-terminal recognition function of factor H in hemolytic uremic syndrome
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BLOOD (2007)
Properdin can initiate complement activation by binding specific target surfaces and providing a platform for de novo convertase assembly
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JOURNAL OF IMMUNOLOGY (2007)
Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains
Matthew C. Pickering et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
The C-terminus of complement factor H is essential for host cell protection
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Two factor H-related proteins from the mouse:: expression analysis and functional characterization
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Critical role of the C-terminal domains of factor H in regulating complement activation at cell surfaces
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Comparison of surface recognition and C3b binding properties of mouse and human complement factor H
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Factor H and atypical hemolytic uremic syndrome: Mutations in the C-terminus cause structural changes and defective recognition functions
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Binding of complement factor H to endothelial cells is mediated by the carboxy-terminal glycosaminoglycan binding site
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Human factor H-related protein 5 has cofactor activity, inhibits C3 convertase activity, binds heparin and C-reactive protein, and associates with lipoprotein
JL McRae et al.
JOURNAL OF IMMUNOLOGY (2005)
FHR-4A:: a new factor H-related protein is encoded by the human FHR-4 gene
M Józsi et al.
EUROPEAN JOURNAL OF HUMAN GENETICS (2005)
Functional analysis in serum from atypical Hemolytic Uremic Syndrome patients reveals impaired protection of host cells associated with mutations in factor H
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MOLECULAR IMMUNOLOGY (2004)
Isolation and characterization of a novel rat factor H-related protein that is up-regulated in glomeruli under complement attack
GH Ren et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
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