期刊
FRONTIERS IN IMMUNOLOGY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2017.00311
关键词
glycolysis; oxidative phosphorylation; immunometabolism; interleukin-17-producing T helper cells; regulatory T cells; autoimmune diseases
类别
资金
- National Health and Medical Research Council of Australia Early Career Fellowship [APP1037633]
- European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program [640116]
- SALK-grant from the government of Flanders, Belgium
- Odysseus-grant of the Research Foundation Flanders, Belgium (FWO)
Interleukin-17-producing T helper (Th17) cells are critical for the host defense of bacterial and fungal pathogens and also play a major role in driving pathogenic autoimmune responses. Recent studies have indicated that the generation of Th17 cells from naive CD4(+) T cells is coupled with massive cellular metabolic adaptations, necessary to cope with different energy and metabolite requirements associated with switching from a resting to proliferative state. Furthermore, Th17 cells have to secure these metabolic adaptations when facing nutrient-limiting environments, such as at the sites of inflammation. Accumulating data indicates that this metabolic reprogramming is significantly linked to the differentiation of T helper cells and, particularly, that the metabolic changes of Th17 cells and anti-inflammatory Forkhead box P3(+) regulatory T cells are tightly and reciprocally regulated. Thus, a better understanding of these processes could offer potential new targets for therapeutic interventions for autoimmune diseases. In this mini-review, we will highlight some of the recent advances and discoveries in the field, with a particular focus on metabolic demands of Th17 cells and their implications for autoimmunity.
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