期刊
FRONTIERS IN IMMUNOLOGY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2017.01787
关键词
intestinal stem cells; peripheral education; fibroblasts; mucosal healing; mesenchymal cells
类别
资金
- Ministry of Education, Culture, Sports, Science, and Technology
- Translational Research Network Program (at the University of Tokyo)
- Leading Initiative for Excellent Young Researchers (LEADER) Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science
- Senri Life Science Foundation
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- Chiba University-UC San Diego Center for Mucosal Immunology, Allergy, and Vaccines
- [23229004]
- [16H06243]
- [17K19550]
- Grants-in-Aid for Scientific Research [26221305] Funding Source: KAKEN
Stromal connective tissue contains mesenchymal cells, including fibroblasts and myofibroblasts, which line the tissue structure. However, it has been identified that the function of mesenchymal cells is not just structural-they also play critical roles in the creation and regulation of intestinal homeostasis. Thus, mucosal mesenchymal cells instruct intestinal immune cell education (or peripheral immune education) and epithelial cell differentiation thereby shaping the local environment of the mucosal immune system. Malfunction of the mesenchymal cell-mediated instruction system (e.g., fibrosis) leads to pathological conditions such as intestinal stricture.
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