期刊
FRONTIERS IN IMMUNOLOGY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2017.00197
关键词
CD4(+) T cells; cytotoxicity; viral infection; virus-driven tumors; immunotherapy
类别
资金
- Italian Association for Cancer Research (AIRC) [IG-17035]
- Progetto di Ricerca di Ateneo, University of Padova
CD4(+) T cells have been and are still largely regarded as the orchestrators of immune responses, being able to differentiate into distinct T helper cell populations based on differentiation signals, transcription factor expression, cytokine secretion, and specific functions. Nonetheless, a growing body of evidence indicates that CD4(+) T cells can also exert a direct effector activity, which depends on intrinsic cytotoxic properties acquired and carried out along with the evolution of several pathogenic infections. The relevant role of CD4(+) T cell lytic features in the control of such infectious conditions also leads to their exploitation as a new immunotherapeutic approach. This review aims at summarizing currently available data about functional and therapeutic relevance of cytotoxic CD4(+) T cells in the context of viral infections and virus-driven tumors.
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