期刊
CURRENT OSTEOPOROSIS REPORTS
卷 15, 期 3, 页码 178-186出版社
SPRINGER
DOI: 10.1007/s11914-017-0362-3
关键词
Non-invasive diagnosis; Bone histomorphometry; Bone biomarkers; Bone turnover; Bone formation; Bone resorption; Chronic kidney disease; Renal osteodystrophy; Diagnostic performance
资金
- Tecomedical
- Diasorin
- Amgen
Purpose of the Review Impaired bone quality contributes to the increased fracture risk in chronic kidney disease patients. Both low and high turnover bone disease may compromise bone quality. The question arises whether bone biomarkers may be additive or replace bone histormorphometry for diagnosing the extremes of bone turnover. Recent Findings Studies exploring the performance of established and emerging bone biomarkers against histomorphometric assessment of bone turnover are limited and overall yield inconclusive results as to their diagnostic utility. Summary Bone biomarkers, although promising, currently fail to meet the needed diagnostic accuracy to replace bone histomorphometry and thus are not yet ready for clinical use. Bone biomarkers have not only several advantages, but also important limitations such as high biological variability, retention with kidney disease, preanalytical issues, and interassay variability. These important issues must be considered when developing and evaluating bone biomarkers. There is an urgent need for harmonization and standardization of available assays and additional bone biopsy studies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据