期刊
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
卷 15, 期 1, 页码 64-67出版社
KOREAN COLL NEUROPSYCHOPHARMACOLOGY
DOI: 10.9758/cpn.2017.15.1.64
关键词
Brain derived neurotrophic factor; Complement protein C1q; Maternal immune activation; Prefrontal cortex; TrkB
资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Strategic Research Program for Brain Sciences from Japan Agency for Medical Research and development, AMED
- Postdoctoral Fellowship for Overseas Researchers of the Japan Society for the Promotion of Science (JSPS) (Tokyo, Japan)
- Grants-in-Aid for Scientific Research [16F14711] Funding Source: KAKEN
Objective: Prenatal infection is implicated in the etiology of schizophrenia. The objective of this paper is to study the role of complement protein C1q in the psychosis of adult offspring after maternal immune activation (MIA). In addition, effect of 7,8 dihy droxyflavone (7,8-DHF: a tropomyosin receptor kinase B [TrkB] agonist) was also examined. Methods: Western blot analysis of C1q in the brain regions from adult offspring after prenatal poly(I:C) (5.0 mg/kg/day from E12 to E17) exposure was performed. 7,8 DHF or vehicle was given from 4 to 8 weeks old. Results: Expression of C1q in the prefrontal cortex (PFC) of adult offspring from poly(I:C) treated pregnant mice was significantly higher than that of control group. Early treatment with 7,8 DHF during juvenile and adolescent stages could prevent an increase of C1q in the PFC of adult offspring after MIA Conclusion: Therefore, it is likely that increased C1q expression in the frontal cortex may play a role in the behavioral abnormal ities of adult offspring after MIA, Furthermore, supplementation with a TrkB agonist such as 7,8 DHF during the prodromal stage may have prophylactic effects on the behavioral abnormalities after MIA.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据