The Relationship between the SNAP-25 Polymorphism and Omission Errors in Korean Children with Attention Deficit Hyperactivity Disorder

Objective: This study aimed to investigate the association between the synaptosomal associated protein 25 kDa (SNAP-25) genotype and performance on the continuous performance test (CPT) in Korean children with attention deficit/hyperactivity disorder (ADHD). Methods: Eighty seven children with ADHD (mean age, 9.23 +/- 1.99 years) participated in this study. Omission errors, commission errors, reaction time, and reaction time variability on the CPT. were analyzed. The single nucleotide polymorphism (SNP) rs3746544 (1065 T>G) of SNAP-25 was genbtyped to examine the association with CPT performance. Results: We found significantly more omission errors on the CPT among children with the 7 genotype of SNAP-25 (t=2.56, p=0.012) after correcting for multiple testing. Conclusion: Our results suggest the possible involvement of the SNAP-25 1065 T>G polymorphism in the inattention phenotype in children with ADHD. Further studies with more refined neuropsychological measures and much larger sample sizes are needed to confirm our findings.