期刊
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
卷 6, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/s13756-017-0279-8
关键词
Burkholderia cepacia complex; Moxifloxacin; Ceftazidime; Colistin; Cystic fibrosis; Antibiotic combinations
类别
资金
- Cystic Fibrosis Canada
- Cystic Fibrosis Trust
- Infection and Immunity Translational Research Group, Northern Ireland HSC
Effective strategies to manage Burkholderia cepacia complex (Bcc) infections in cystic fibrosis (CF) patients are lacking. We tested combinations of clinically available antibiotics and show that moxifloxacin-ceftazidime could inhibit 16 Bcc clinical isolates at physiologically achievable concentrations. Adding low dose of colistin improved the efficacy of the combo, especially at conditions mimicking CF respiratory secretions.
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