期刊
ADVANCED SCIENCE
卷 4, 期 12, 页码 -出版社
WILEY
DOI: 10.1002/advs.201700401
关键词
biomimetic materials; cell delivery; lotus root-like biomaterials; tissue regeneration
资金
- National Key Research and Development Program of China [2016YFB0700803]
- National Natural Science Foundation of China [31370963, 81430012]
- CAS [QYZDB-SSW-SYS027]
- Science and Technology Commission of Shanghai Municipality [17441903700, 16DZ2260603, 15XD1503900]
Biomimetic materials have drawn more and more attention in recent years. Regeneration of large bone defects is still a major clinical challenge. In addition, vascularization plays an important role in the process of large bone regeneration and microchannel structure can induce endothelial cells to form rudimentary vasculature. In recent years, 3D printing scaffolds are major materials for large bone defect repair. However, these traditional 3D scaffolds have low porosity and nonchannel structure, which impede angiogenesis and osteogenesis. In this study, inspired by the microstructure of natural plant lotus root, biomimetic materials with lotus root-like structures are successfully prepared via a modified 3D printing strategy. Compared with traditional 3D materials, these biomimetic materials can significantly improve in vitro cell attachment and proliferation as well as promote in vivo osteogenesis, indicating potential application for cell delivery and bone regeneration.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据