期刊
MOLECULAR & CELLULAR ONCOLOGY
卷 3, 期 3, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2016.1143546
关键词
Autophagy; cell size control; cancer; inflammation; myopathy; mevalonate pathway; proteostasis; RAB11; statins; senescence
类别
Autophagy is responsible for the degradation and recycling of cellular proteins and organelles. Our recent work shows that the mevalonate pathway influences cell size, growth, and proteostasis by regulating basal autophagic flux through geranylgeranylation of the small GTPase RAB11. The control of autophagy by the mevalonate/cholesterol pathway has potential implications for statin toxicity, inflammation, cancer, and neurodegenerative diseases.
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