期刊
ADVANCED SCIENCE
卷 5, 期 3, 页码 -出版社
WILEY
DOI: 10.1002/advs.201700481
关键词
cancer therapy; heptamethine cyanine dye; mitochondria targeting; near-infrared (NIR) dye; photodynamic therapy
资金
- Advanced Biomass R&D Center (ABC) of the Global Frontier Project - Ministry of Science, ICT, and Future Planning [NRF-2015M3A6A2074238]
- Ministry of Science, ICT, and Future Planning [NRF-2014M3A9E4064580, NRF-2016R1A2B4009619]
- National Research Foundation of Korea [2016R1A2B4009619] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
A noninvasive and selective therapy, photodynamic therapy (PDT) is widely researched in clinical fields; however, the lower efficiency of PDT can induce unexpected side effects. Mitochondria are extensively researched as target sites to maximize PDT effects because they play crucial roles in metabolism and can be used as cancer markers due to their high transmembrane potential. Here, a mitochondria targeting photodynamic therapeutic agent (MitDt) is developed. This photosensitizer is synthesized from heptamethine cyanine dyes, which are conjugated or modified as follows. The heptamethine mesoposition is conjugated with a triphenylphosphonium derivative for mitochondrial targeting, the N-alkyl side chain is modified for regulation of charge balance and solubility, and the indolenine groups are brominated to enhance reactive oxygen species generation (ROS) after laser irradiation. The synthesized MitDt increases the cancer uptake efficiency due to the lipo-cationic properties of the triphenylphosphonium, and the PDT effects of MitDt are amplified after laser irradiation because mitochondria are susceptible to ROS, the response to which triggers an apoptotic anticancer effect. Consequently, these hypotheses are demonstrated by in vitro and in vivo studies, and the results indicate strong potential for use of MitDts as efficient single-molecule-based PDT agents for cancer treatment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据