期刊
MOLECULAR & CELLULAR ONCOLOGY
卷 3, 期 4, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2015.1071303
关键词
AMPK; AML; GSK621; mTORC1; synthetic lethality
类别
We report the therapeutic potential of GSK621, an AMP-activated protein kinase (AMPK) agonist, in acute myeloid leukemia (AML). GSK621-induced cytotoxicity is restricted to AML cells compared to normal hematopoietic progenitors due to a unique synthetic lethal interaction of co-activation of AMPK and mammalian target of rapamycin complex 1 (mTORC1) that involves the stress response pathway. AMPK activation thus represents an attractive perspective for cancer therapy.
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