期刊
JAPANESE JOURNAL OF VETERINARY RESEARCH
卷 64, 期 4, 页码 265-271出版社
HOKKAIDO UNIV
DOI: 10.14943/jjvr.64.4.265
关键词
handling; mouse; stress
资金
- JSPS KAKENHI [25925011]
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Grants-in-Aid for Scientific Research [25925011] Funding Source: KAKEN
The three different mouse handling methods, picking up by tails, tunnels, and open hands were performed using the ICGN glomerulonephritis mouse and the severity of symptoms was evaluated. The handling groups exhibited a tendency of more severe symptoms than the non-handling control group. Female mice handled by their tails showed significantly more severe symptoms than the control group. In addition, we subjected the normal laboratory mice, C57BL/6 and BALB/c mice to tail and tunnel handling to assess the stress conditions. The plasma corticosterone level in the tail-handled mice was higher than that in control mice. These results indicate that handling causes stress and may affect the phenotype of disease model mice.
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