期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 4, 期 11, 页码 3658-3677出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.7b00514
关键词
cell surface engineering; polymers; bioconjugation; red blood cells; stem cells; islet cells; endothelial cells
资金
- Canadian Institutes of Health Research (CIHR)
- Natural Sciences and Engineering Research Council (NSERC) of Canada
- Michael Smith Foundation for Health Research (MSFHR)
- MSFHR postdoctoral fellowship
- Centre for Blood Research
- Canadian Blood Services
- NSERC CREATE NanoMat Program
- MITACS Canada
The introduction of cell-based therapies has provided new and unique strategies to treat many diseases and disorders including the recent approval of CAR-T cell therapy for the leukemia. Cell surface engineering is a methodology in which the cell surface is tailored to modulate cellular function and interactions. In addition to genetic engineering of cell surface proteins, a wide array of robust, innovative and elegant approaches have been developed to selectively target the cell surface. In this review, we will introduce the leading strategies currently used in cell surface engineering including broadly reactive chemical ligations and physical associations as well as more controlled approaches as demonstrated in genetic, enzymatic and metabolic engineering. Prominent applications of these strategies for cell-based therapies will be highlighted including targeted cell death, control over stem cell fate, immunoevasion, blood transfusion and the delivery of cells to target tissues. Advances will be focused specifically on cells which are the most promising in generating cell-based therapeutics including red blood cells, white blood cells (lymphocytes, macrophages), stem cells (multipotent and pluripotent), islet cells, cancer cells, and endothelial cells.
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