期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 3, 期 10, 页码 2215-2222出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.7b00383
关键词
biopolymer; transplantation; biomimics; subcutaneous; vascularization
资金
- Province of Alberta, Alberta Innovates Technology Futures
- National Institute for Nanotechnology
- Canadian Institutes of Health Research (CIHR) [MOP 119500]
- Juvenile Diabetes Research Foundation [3-SRA-2016-252-S-B]
Polymeric scaffolds containing biomimics offer exciting therapies with broad potential impact for cellular therapies and thereby potentially improve success rates. Here we report the designing and fabrication of a hybrid scaffold that can prevent a foreign body reaction and maintain cell viability. A biodegradable acrylic based cross-linkable polycaprolactone based polymer was developed and using a multihead electrospinning station to fabricate hybrid scaffolds. This consists of cell growth factor mimics and factors to prevent a foreign body reaction. Transplantation studies were performed subcutaneously and in epididymal fat pad of immuno-competent Balb/c mice and immuno-suppressed B6 Ragl mice and we demonstrated extensive neo-vascularization and maintenance of islet cell viability in subcutaneously implanted neonatal porcine islet cells for up to 20 weeks of post-transplant. This novel approach for cell transplantation can improve the revascularization and allow the integration of bioactive molecules such as cell adhesion molecules, growth factors, etc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据