期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 3, 期 9, 页码 2064-2075出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.7b00338
关键词
silk; fibroin; multiphoton lithography; hydrogel; IgG
资金
- Air Force Office of Scientific Research
Regenerated silk fibroin, a biopolymer derived from silkworm cocoons, is a versatile material that has been widely explored for a number of applications (e.g., drug delivery, tissue repair, biocompatible electronics substrates, and optics) due to its attractive biochemical properties and processability. Here, we report on the free-form printing of silk-based, 3D microstructures through multiphoton lithography. Utilizing multiphoton lithography in conjunction with specific photoinitiator chemistry and postprint cross-linking, a number of microarchitectures were achieved including self-supporting fibroin arches. Further, the straightforward production of high fidelity and biofunctional protein architectures was enabled through the printing of aqueous fibroin/immunoglobulin solutions.
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