期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 3, 期 10, 页码 2470-2479出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.7b00299
关键词
graphene oxide incorporation; polyethylene glycol based cryogel; mesenchymal stem cells; osteogenesis; bone tissue engineering
资金
- Seoul National University Dental Hospital Research Fund [01-2015-0006]
- National Research Foundation of Korea (KNRF) - Ministry of Education, Science and Technology [NRF-2016R1E1A1A01943393]
- National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2015H1A2A1029321]
- National Research Foundation of Korea [2015H1A2A1029321] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Graphene oxide (GO) is considered a comparatively recent biomaterial with enormous potential because of its nontoxicity, high dispersity, and enhanced interaction with biomolecules. These characteristics of GO can promote the interactions between the substrates and cell surfaces. In this study, we incorporated GO in a cryogel-based scaffold system to observe their influence on the osteogenic responses of human tonsil-derived mesenchymal stem cells (hTMSCs). Compared to polyethylene glycol (PEG)-based cryogel scaffold, GO-embedded PEG-based (PEGDA-GO) cryogels not only showed improved cell attachment and focal adhesion kinase (FAK) signaling activation but also enhanced cell viability. Taken together, we demonstrated that PEGDA-GO cryogels can stimulate osteogenic differentiation under an osteoinductive condition and enhance osteogenic phenotypes compared to the control group. In summary, we demonstrate that GO embedded in cryogels system is an effective biofunctionalizing scaffold to control osteogenic commitment of stem cells.
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