期刊
STEM CELL REPORTS
卷 8, 期 3, 页码 561-575出版社
CELL PRESS
DOI: 10.1016/j.stemcr.2017.01.006
关键词
-
资金
- [20116004]
- [24247041]
- [25114004]
- [24111002]
- [25114002]
- Grants-in-Aid for Scientific Research [25114007, 26713012, 25114004, 15H04380, 15H05856, 26870077, 15H05865] Funding Source: KAKEN
In the seminiferous tubules of mouse testes, a population of glial cell line-derived neurotrophic factor family receptor alpha 1 (GFR alpha 1)positive spermatogonia harbors the stem cell functionality and supports continual spermatogenesis, likely independent of asymmetric division or definitive niche control. Here, we show that activation of Wnt/beta-catenin signaling promotes spermatogonial differentiation and reduces the GFR alpha 1(+) cell pool. We further discovered that SHISA6 is a cell-autonomous Wnt inhibitor that is expressed in a restricted subset of GFRa1(+) cells and confers resistance to the Wnt/b-catenin signaling. Shisa6(+) cells appear to show stem cell-related characteristics, conjectured from the morphology and long-term fates of T (Brachyury)(+) cells that are found largely overlapped with Shisa6(+) cells. This study proposes a generic mechanism of stem cell regulation in a facultative (or open) niche environment, with which different levels of a cell-autonomous inhibitor (SHISA6, in this case) generates heterogeneous resistance to widely distributed differentiation-promoting extracellular signaling, such as WNTs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据