期刊
STEM CELL REPORTS
卷 9, 期 1, 页码 177-189出版社
CELL PRESS
DOI: 10.1016/j.stemcr.2017.05.035
关键词
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资金
- California Institute of Regenerative Medicine [RB1-01417, TR1-01257]
- NIH [1R01EY019101, 5P30AG010129, 5RC1AG036022-02, 2P51RR000169-49]
- NSF [MCB0951199]
- UC Davis Dermatology Developmental Fund
- Research to Prevent Blindness
- NSFC [31371406]
- STCSM [13ZR1424500]
- SMHS [XYQ2013094]
- SMC-Star Award
- Shriners of Northern California
- MOST [2012CB518100]
- CIRM
Limited migration of neural stem cells in adult brain is a roadblock for the use of stem cell therapies to treat brain diseases and injuries. Here, we report a strategy that mobilizes and guides migration of stem cells in the brain in vivo. We developed a safe stimulation paradigm to deliver directional currents in the brain. Tracking cells expressing GFP demonstrated electrical mobilization and guidance of migration of human neural stem cells, even against co-existing intrinsic cues in the rostral migration stream. Transplanted cells were observed at 3 weeks and 4 months after stimulation in areas guided by the stimulation currents, and with indications of differentiation. Electrical stimulation thus may provide a potential approach to facilitate brain stem cell therapies.
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