期刊
STEM CELL REPORTS
卷 9, 期 1, 页码 23-31出版社
CELL PRESS
DOI: 10.1016/j.stemcr.2017.04.031
关键词
-
资金
- Cancer Center Support Grant [5P30CA045508, 5P30CA045508-28]
- P01 award [2P01CA013106]
- Sidney Kimmel Cancer Foundation
- Pershing Square Innovator Award
- Rita Allen Scholar Award
- V-foundation Scholar Award
- Manhasset Coalition Against Breast Cancer Award
- Cancer Research UK [21143] Funding Source: researchfish
Chromatin remodeling is a key requirement for transcriptional control of cellular differentiation. However, the factors that alter chromatin architecture in mammary stem cells (MaSCs) are poorly understood. Here, we show that BPTF, the largest subunit of the NURF chromatin remodeling complex, is essential for MaSC self-renewal and differentiation of mammary epithelial cells (MECs). BPTF depletion arrests cells at a previously undefined stage of epithelial differentiation that is associated with an incapacity to achieve the luminal cell fate. Moreover, genome-wide analysis of DNA accessibility following genetic or chemical inhibition, suggests a role for BPTF in maintaining the open chromatin landscape at enhancers regions in MECs. Collectively, our study implicates BPTF in maintaining the unique epigenetic state of MaSCs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据