期刊
FEMS MICROBIOLOGY ECOLOGY
卷 92, 期 12, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/femsec/fiw191
关键词
ulcerative colitis; intestinal inflammation; gut microbiota; metagenomics; dysbiosis; probiotic bacteria
类别
资金
- GenProbio srl
- Fondazione Caritro, Trento, Italy
- Science Foundation Ireland (SFI), through the Irish Government's National Development Plan [SFI/12/RC/2273]
- SFI [13/IA/1953]
- EU Joint Programming Initiative-A Healthy Diet for a Healthy Life (JPI HDHL
- MIUR
Ulcerative colitis (UC) is associated with a substantial alteration of specific gut commensals, some of which may be involved in microbiota-mediated protection. In this study, microbiota cataloging of UC patients by 16S rRNA microbial profiling revealed a marked reduction of bifidobacteria, in particular the Bifidobacterium bifidum species, thus suggesting that this taxon plays a biological role in the aetiology of UC. We investigated this further through an in vivo trial by testing the effects of oral treatment with B. bifidum PRL2010 in a wild-type murine colitis model. TNBS-treated mice receiving 10(9) cells of B. bifidum PRL2010 showed a marked reduction of all colitis-associated histological indices as well as maintenance of mucosal integrity as it was shown by the increase in the expression of many tight junction-encoding genes. The protective role of B. bifidum PRL2010, as well as its sortase-dependent pili, appears to be established through the induction of an innate immune response of the host. These results highlight the importance of B. bifidum as a microbial biomarker for UC, revealing its role in protection against experimentally induced colitis.
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