期刊
EUROPEAN POLYMER JOURNAL
卷 69, 期 -, 页码 559-572出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.eurpolymj.2015.02.014
关键词
RAFT polymerization; Drug delivery; Graphene; Biodegradable release; PH-responsive; pi-pi stacking interaction
资金
- Natural Science Foundation of China [51173087, 21305133]
- Taishan Scholars Program
- Jilin Province Science and Technology Development Plan Project [201201006]
- Natural Science Foundation of Shandong [ZR2011EMM001]
A novel tri-block copolymer poly(oxopentanoate ethyl methacrylate)-block-poly(pyridyl disulfide ethyl acrylate)-block-poly(ethylene glycol acrylate) [poly(OEMA-b-PDEA-b-PEGA)], retaining active keto groups and pyridyl disulfide (PDS) side functionalities, was synthesized as a drug delivery vehicle using reversible addition-fragmentation chain transfer (RAFT) polymerization method. One mimic drug pyridine-2-thione (PT) was introduced into the monomer, PDEA for copolymerization. The other mimic drug O-benzylhydroxylamine (BHA) was conjugated with tri-block copolymer via efficient oxime coupling chemistry, followed by the attachment onto graphene via pi-pi stacking interaction to obtain a graphene/tri-block copolymer composite. H-1 NMR, UV-vis absorption spectroscopy, fluorescence spectroscopy, gel permeation chromatography (GPC), atomic force microscope (AFM) and transmission electron microscope (TEM) were used to verify the successful step-wise preparation of the tri-block copolymer and drug loaded composite. In vitro release behaviors of BHA and PT from graphene/tri-block copolymer composite via dual drug release mechanisms were investigated. BHA can be released under acid environment, while PT will be released in the presence of reducing agents, such as dithiothreitol (DTT) or glutathione (GSH). It can be envisioned that this novel composite could be exploited as a novel intracellular drug delivery system via dual release mechanisms. (C) 2015 Elsevier Ltd. All rights reserved.
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