期刊
EUROPEAN POLYMER JOURNAL
卷 62, 期 -, 页码 145-154出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.eurpolymj.2014.11.020
关键词
PLLA; Nanopartides; Magnetic properties; Nanocomposite; Iron oxide; Encapsulation
资金
- Italian MIUR through project FIRB Riname [RBAP114AMK]
- Fondazione CARIPLO through project BaTIVIAN [2013-0752]
- CICYT, Spain [MAT2012-31759]
- Ente Cassa di Risparmio di Firenze
This study describes an innovative strategy to develop advanced multifunctional materials, by embedding magnetic nanoparticles in biodegradable poly(L-lactide) (PLLA) nanospheres. The morphology, size distribution and composition of the nanocomposite particles were investigated by several techniques, demonstrating the successful incorporation of the magnetic nanoparticles into monodisperse polymer nanospheres with average diameter of 130 nm. The effect of the encapsulation on the magnetic behaviour was evaluated by magnetometry techniques and the hyperthermic properties of PLLA embedded nanoparticles were investigated. This study suggested that the combination of the hydrophilic, biocompatible polyvinyl alcohol (PVA), used as surfactant, with the biodegradable and biocompatible PLLA and superparamagnetic nanoparticles is a promising strategy worth further implementing to obtain a magneto-active nanocomposite suitable for biomedical applications such as magnetic cell targeting and drug delivery with thermally induced release. (C) 2014 Elsevier Ltd. All rights reserved.
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