4.6 Article

Estrogen therapy offsets thermal impairment of vitellogenesis, but not zonagenesis, in maiden spawning female Atlantic salmon (Salmo salar)

期刊

PEERJ
卷 5, 期 -, 页码 -

出版社

PEERJ INC
DOI: 10.7717/peerj.3897

关键词

Gene expression; Temperature; Salmon; Ovarian steroidogenesis; Climate change; Aquaculture; Hormonal therapy

资金

  1. Australian Fisheries Research & Development Corporation [2008/217]
  2. Australian Seafood Cooperative Research Centre [2008/762, 2010/719]
  3. Salmon Enterprises of Tasmania Pty. Ltd. (Saltas)
  4. Australian Post Graduate Award through the University of the Sunshine Coast

向作者/读者索取更多资源

In female Atlantic salmon (Salmo salar ), exposure to warm summer temperatures causes a reduction in plasma 17 beta-estradiol (E2), which impairs downstream vitellogenesis and zonagenesis, and reduces egg fertility and embryo survival. The aim of the present study was to determine whether E2-treatment could offset thermal impairment of endocrine function and maintain egg quality in maiden (first-time-spawning) S. salar reared at 22 degrees C. Treatment with E2 at 22 degrees C stimulated vitellogenin (vtg ) gene expression and subsequent protein synthesis which promoted oocyte growth and increased egg size relative to untreated fish at 14 and 22 degrees C. However, E2-treatment at 22 degrees C was not associated with an increase in egg fertility and embryo survival relative to untreated fish at 22 degrees C, despite the positive effects of E2-treatment on vitellogenesis and oocyte growth. As there was no evidence to suggest that the estrogen receptor alpha expression was suppressed by high temperature, this could be due to the lack of stimulation on zonagenesis by E2-treatment observed at high temperature during oocyte development. Our results demonstrate that treatment with E2 is not able to maintain zonagenesis or egg quality in maiden S. salar at high temperature, even when vtg gene expression, protein synthesis and subsequent oocyte growth is promoted. This implies that the mechanisms regulating zonagenesis, but not vitellogenesis are impaired at elevated temperature in female S. salar broodstock, and highlights the remarkable complexity of thermally induced endocrine disruption in fish.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据