期刊
EUROPEAN POLYMER JOURNAL
卷 66, 期 -, 页码 149-159出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.eurpolymj.2015.01.047
关键词
Shear-thinning; Supramolecular hydrogels; Photodynamic therapy; Drug delivery; Block copolymer
资金
- National Natural Science Foundation of China [21004031]
- Natural Science Foundation of Jiangsu Province [BK2011459]
- National Postdoctoral Foundation of China [20090461065]
- National Postdoctoral Foundation of Jiangsu Province [1001034B]
- Open Foundation of Stake Key Laboratory of Natural and Biomimetic Drugs, Peking University [K20110105]
- Social Development Foundation of Zhen Jiang [SH2012024]
- Practice Innovation Program of Jiang Su [SJZZ-0138]
An amphiphilic porphyrin-cored, star-shaped poly (epsilon-caprolactone)-b-poly (ethylene glycol) (SPPCL-b-PEG) copolymer was synthesized and used as a building block for constructing supramolecular hydrogels. With the aid of alpha-cyclodextrin (alpha-CD), thixotropic and reversible supramolecular hydrogel could be formed by copolymers based on the host-guest inclusion complexation (IC). Due to the biodegradable and biocompatible properties, this IC-based supramolecular hydrogel was used as carrier for doxorubicin (DOX) delivery systems. The release results presented a triphasic drug-release profile and the release of this system lasted more than 3 weeks. Also, upon irradiation with light (650 nm), cytotoxic singlet oxygen (O-1(2)) could be generated by porphyrin core and easily released from hydrogel matrix. Considering that both sustained-release drug delivery of hydrogels and porphyrin for photodynamic therapy (PDT) were achieved in a combined compound, this shear-thinning supramolecular hydrogel with porphyrin was elaborately designed as a promising replacement therapy to medium or advanced cancer for surgery. (C) 2015 Elsevier Ltd. All rights reserved.
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