期刊
ONCOGENESIS
卷 6, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/oncsis.2017.14
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资金
- Rotary Club of Belmont
- Australian Rotary Health Research Fund
- Curtin University School of Biomedical Sciences
- NHMRC Early Career Fellowship [GNT1054245]
- Cancer Council of Western Australia Suzanne Cavanagh Early Career Investigator Grant
- Raine Priming Grant
- strategic research funds from the School of Biomedical Sciences (Curtin University)
- Commercialization Advisory Board of Curtin University
- Cancer Council of Western Australia
- Actinogen Ltd, Perth, Western Australia
Wnt signaling regulates a variety of cellular processes, including cell fate, differentiation, proliferation and stem cell pluripotency. Aberrant Wnt signaling is a hallmark of many cancers. An aggressive subtype of breast cancer, known as triple-negative breast cancer (TNBC), demonstrates dysregulation in canonical and non-canonical Wnt signaling. In this review, we summarize regulators of canonical and non-canonical Wnt signaling, as well as Wnt signaling dysfunction that mediates the progression of TNBC. We review the complex molecular nature of TNBC and the emerging therapies that are currently under investigation for the treatment of this disease.
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