期刊
NUCLEUS
卷 8, 期 2, 页码 156-161出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/19491034.2016.1263411
关键词
cell lysis; cPL; cell swelling; inflammatory signals; membrane tension; mechanosensing; nuclear envelope
类别
资金
- NIH [GM099970]
- American Asthma Foundation Scholar grant
Most research in nuclear mechanotransduction has focused on the nuclear lamina and lamin binding proteins. These structures provide mechanical stability to the nucleus, establish a link between the cytoskeleton and chromatin, and can transmit mechanical signals. At the same time, mechanical perturbations to the nucleus also affect its phospholipid membranes. In this commentary, we discuss how changes in nuclear membrane tension can mediate mechanotransduction.
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