期刊
NEUROIMAGE-CLINICAL
卷 14, 期 -, 页码 354-362出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.nicl.2017.02.002
关键词
Transcranial magnetic stimulation; Electroencephalography; Positron emission tomography; Disorders of consciousness; Unresponsive wakefulness syndrome minimally conscious state; Brain injury
类别
资金
- Belgian National Fund for Scientific Research (FNRS)
- Human Brain Project [EU-H2020-FETFLAGSHIP-HBP-SGA1-GA720270]
- Luminous project [EU-H2020-FETOPEN-GA686764]
- Belgian American Education Foundation
- Wallonie-Bruxelles International
- European Commission
- Fonds Leon Fredericq
- James S. McDonnell Foundation
- Mind Science Foundation
- French Speaking Community Concerted Research Action [ARC-06/11-340]
- University and University Hospital of Liege
Background: Making an accurate diagnosis in patients with disorders of consciousness remains challenging. F-18-fluorodeoxyglucose (FDG)-PET has been validated as a diagnostic tool in this population, and allows identifying unresponsive patients with a capacity for consciousness. In parallel, the perturbational complexity index (PCI), a new measure based on the analysis of the electroencephalographic response to transcranial magnetic stimulation, has also been suggested as a tool to distinguish between unconscious and conscious states. The aim of the study was to cross-validate FDG-PET and PCI, and to identify signs of consciousness in otherwise unresponsive patients. Methods: We jointly applied the Coma Recovery Scale-Revised, FDG-PET and PCI to assess 24 patients with non-acute disorders of consciousness or locked-in syndrome(13 male; 19-54 years old; 12 traumatic; 9 unresponsive wakefulness syndrome, 11 minimally conscious state; 2 emergence from the minimally conscious state, and 2 locked-in syndrome). Results: FDG-PET and PCI provided congruent results in 22 patients, regardless of their behavioural diagnosis. Notably, FDG-PET and PCI revealed preserved metabolic rates and high complexity levels in four patients who were behaviourally unresponsive. Conclusion: We propose that jointly measuring the metabolic activity and the electrophysiological complexity of cortical circuits is a useful complement to the diagnosis and stratification of patients with disorders of consciousness. (C) 2017 The Authors. Published by Elsevier Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据