期刊
NEUROIMAGE-CLINICAL
卷 13, 期 -, 页码 16-23出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.nicl.2016.11.013
关键词
Tourette syndrome; ADHD; Glutamate; Fronto-striatal circuit; MRS
类别
资金
- European Community's Seventh Framework Programme TACTICS [278948]
- TS-EUROTRAIN [316978]
Objective: Both Tourette's disorder (TD) and attention-deficit/hyperactivity disorder (ADHD) have been related to abnormalities in glutamatergic neurochemistry in the fronto-striatal circuitry. TD and ADHD often co-occur and the neural underpinnings of this co-occurrence have been insufficiently investigated in prior studies. Method: We used proton magnetic resonance spectroscopy (1H-MRS) in children between 8 and 12 years of age (TD n = 15, ADHD n = 39, TD + ADHD n = 29, and healthy controls n = 53) as an in vivo method of evaluating glutamate concentrations in the fronto-striatal circuit. Spectra were collected on a 3 Tesla Siemens scanner from two voxels in each participant: the anterior cingulate cortex (ACC) and the left dorsal striatum. LC-model was used to process spectra and generate glutamate concentrations in institutional units. A one-way analysis of variance was performed to determine significant effects of diagnostic group on glutamate concentrations. Results: We did not find any group differences in glutamate concentrations in either the ACC (F-(3132)= 0.97, p = 0.41) or striatum (F-(3121) = 0.59, p = 0.62). Furthermore, variation in glutamate concentration in these regions was unrelated to age, sex, medication use, IQ, tic, or ADHD severity. Obsessive-compulsive (OC) symptoms were positively correlated with ACC glutamate concentration within the participants with TD (rho = 0.35, p(uncorrected) = 0.02). Conclusion: We found no evidence for glutamatergic neuropathology in TD or ADHD within the fronto-striatal circuits. However, the correlation of OC-symptoms with ACC glutamate concentrations suggests that altered glutamatergic transmission is involved in OC-symptoms within TD, but this needs further investigation. (C) 2016 The Authors. Published by Elsevier Inc.
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