期刊
NANOMATERIALS
卷 7, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/nano7050094
关键词
gene delivery; nanomaterials; non-viral vectors; siRNA
类别
资金
- U.S. Department of Energy's Office of Energy Efficiency and Renewable Energy, Bioenergy Technologies Office
- U.S. DOE's International Affairs [DE-PI0000031]
- McKnight Foundation
- UF Plant Molecular AMP
- Cellular Biology graduate program
With the rapid development of nanotechnology in the recent decade, novel DNA and RNA delivery systems for gene therapy have become available that can be used instead of viral vectors. These non-viral vectors can be made of a variety of materials, including inorganic nanoparticles, carbon nanotubes, liposomes, protein and peptide-based nanoparticles, as well as nanoscale polymeric materials. They have as advantages over viral vectors a decreased immune response, and additionally offer flexibility in design, allowing them to be functionalized and targeted to specific sites in a biological system with low cytotoxicity. The focus of this review is to provide an overview of novel nanotechnology-based methods to deliver DNA and small interfering RNAs into biological systems.
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