期刊
NANOMATERIALS
卷 7, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/nano7030070
关键词
surface-enhanced Raman scattering; melanin-Ag nanocomposites; bioimaging; melanogenesis
类别
资金
- National Natural Science Foundation of China [61335011, 61675072, 61275187, 21505047, 31300691, 11404116]
- Natural Science Foundation of Guangdong Province of China [2014A030310306, S2013040016223, 2014A030311024]
- Science and Technology Project of Guangdong Province of China [2012A080203008, 2014A020212282]
- Science and Technology Innovation Project of the Education Department of Guangdong Province of China [2013KJCX0052]
- Guangdong Medical Scientific Research Fund [A2016161]
- Scientific Research Cultivating Fund of JINAN University [11616332]
- Entrusted Technology Development Projects of Infinitus (China) Co., Ltd. [HPG/2013/11/1598]
Melanin plays an indispensable role in the human body. It serves as a biological reducer for the green synthesis of precious metal nanoparticles. Melanin-Ag nanocomposites were successfully produced which exhibited very strong surface-enhanced Raman scattering (SERS) effect because of the reducibility property of melanin. A melanin-Ag composite structure was synthesized in situ in melanin cells, and SERS technique was performed for the rapid imaging and quantitative assay of intracellular melanin. This imaging technique was also used to successfully trace the formation and secretion of intracellular melanin after stimulation with melanin-stimulating hormones. Based on the self-reducing property of melanin, the proposed SERS imaging method can provide potentially powerful analytical detection tools to study the biological functions of melanin and to prevent and cure melanin-related diseases.
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