期刊
NANOMATERIALS
卷 7, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/nano7040087
关键词
nanomaterial; laser desorption/ionization; time-of-flight mass spectrometry; small biological molecules; environmental pollutants
类别
资金
- National Nature Science Foundation of China [21477033, 21305029, 21275020]
- Program for Science& Technology Innovation Talents in Universities of Henan Province [17HASTIT003]
- Program for Excellent Youth Scholars in Higher Education of Henan Province [2014GGJS-024]
Matrix-assisted laser desorption/ionization (MALDI), a soft ionization method, coupling with time-of-flight mass spectrometry (TOF MS) has become an indispensible tool for analyzing macromolecules, such as peptides, proteins, nucleic acids and polymers. However, the application of MALDI for the analysis of small molecules (<700 Da) has become the great challenge because of the interference from the conventional matrix in low mass region. To overcome this drawback, more attention has been paid to explore interference-free methods in the past decade. The technique of applying nanomaterials as matrix of laser desorption/ionization (LDI), also called nanomaterial-assisted laser desorption/ionization (nanomaterial-assisted LDI), has attracted considerable attention in the analysis of low-molecular weight compounds in TOF MS. This review mainly summarized the applications of different types of nanomaterials including carbon-based, metal-based and metal-organic frameworks as assisted matrices for LDI in the analysis of small biological molecules, environmental pollutants and other low-molecular weight compounds.
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