期刊
NANOMATERIALS
卷 7, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/nano7060122
关键词
nanostructured lipid carriers; polymeric nanoparticles; lipid-polymer hybrid nanoparticles; structure; preparation; applications
类别
资金
- National Natural Science Foundation of China [81273707]
- Ministry of Education in the New Century Excellent Talents [NECT-12-0677]
- Natural Science Foundation of Guangdong [S2013010012880, 2016A030311037]
- Science and Technology Program of Guangzhou [2014J4500005, 201704030141]
- Science Program of the Department of Education of Guangdong [2013KJCX0021, 2015KGJHZ012]
- Science and Technology Program of Guangdong [2015A050502027]
Nanostructured lipid carriers (NLCs) are modified solid lipid nanoparticles (SLNs) that retain the characteristics of the SLN, improve drug stability and loading capacity, and prevent drug leakage. Polymer nanoparticles (PNPs) are an important component of drug delivery. These nanoparticles can effectively direct drug delivery to specific targets and improve drug stability and controlled drug release. Lipid-polymer nanoparticles (PLNs), a new type of carrier that combines liposomes and polymers, have been employed in recent years. These nanoparticles possess the complementary advantages of PNPs and liposomes. A PLN is composed of a core-shell structure; the polymer core provides a stable structure, and the phospholipid shell offers good biocompatibility. As such, the two components increase the drug encapsulation efficiency rate, facilitate surface modification, and prevent leakage of water-soluble drugs. Hence, we have reviewed the current state of development for the NLCs', PNPs', and PLNs' structures, preparation, and applications over the past five years, to provide the basis for further study on a controlled release drug delivery system.
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