期刊
NANOMATERIALS
卷 7, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/nano7040085
关键词
magnetic nanoparticles; doxorubicin; chitosan; remote delivery; antitumor effect
类别
资金
- Taiwan Ministry of Science and Technology Grant [MOST105-2628-E-110-001-MY3, MOST105-2628-B-110-004-MY3]
In clinical tumor therapy, chemotherapeutic routes have caused severe side effects; current delivery methods are unsatisfactory. Successful design of a remotely folate (FA)-grafted chitosan (CS)-coated magnetic nanoparticle (MNP) with low toxicity, has been achieved. A chemotherapeutic drug such as doxorubicin (DOX), is loaded in the MNP-based matrix (FA-grafted CS-DOX-(TPP)-MNP), which is coated by an activated target tumor molecule of FA-grafted CS biopolymer with the inclusion of tripolyphosphate (TPP) as a linker. The resultant nano-complexes exhibited random aggregates (similar to 240 nm) and zeta potential (-24.9 mV). In vivo experiments using athymic BALB/c nude mice with human glioblastoma U87 cells in a subcutaneous tumor model revealed that magnetic guidance of FA-grafted CS-DOX-(TPP)-MNP, injected via the tail vein, significantly decreased tumor growth. This manuscript demonstrates the feasibility of magnetizing control of FA-grafted CS-DOX-(TPP)-MNP to enhance the localization of drug release.
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