期刊
MULTIPLE SCLEROSIS AND RELATED DISORDERS
卷 18, 期 -, 页码 90-92出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.msard.2017.09.023
关键词
Myelin oligodendrocyte glycoprotein (MOG); N-methyl-D-aspartate receptor (NMDAR); Autoimmune encephalitis (AIE)
资金
- National Natural Science Foundation of China [81771296, 81200919]
We report the case of a patient who initially presented with fever, headache and seizure. MRI revealed a fluid attenuation inversion recovery (FLAIR) high-intensity lesion involving the right temporal, parietal and occipital cortex. Afterwards, the patient developed three recurrent episodes, manifested as brainstem encephalitis, optic neuritis and ADEM-like illness successively, indicating demyelination. Both of his serum anti-MOG and CSF anti NMDAR antibodies were proved positive by transfected cell based assays. We consider our case to have cortical encephalitis due to certain autoimmune mechanism initially, and then developed MOG-antibody mediated recurrent demyelination in the following episodes.
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