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miR-134: A Human Cancer Suppressor?

期刊

MOLECULAR THERAPY-NUCLEIC ACIDS
卷 6, 期 -, 页码 140-149

出版社

CELL PRESS
DOI: 10.1016/j.omtn.2016.11.003

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资金

  1. National Natural Science Foundation of China [81271943, 81360447, 81372973]
  2. Scientific and Technological Innovation Team of High-tech Industries of Wuhan Municipal Science and Technology Bureau [2015070504020219]
  3. Fundamental Research Funds for the Central Universities [2015305020202]

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NMicroRNAs (miRNAs) are small noncoding RNAs approximately 20-25 nt in length, which play crucial roles through directly binding to corresponding 30 UTR of targeted mRNAs. It has been reported that miRNAs are involved in numerous of diseases, including cancers. Recently, miR-134 has been identified to dysregulate in handles of human cancers, such as lung cancer, glioma, breast cancer, colorectal cancer, and so on. Increasing evidence indicates that miR-134 is essential for human carcinoma and participates in tumor cell proliferation, apoptosis, invasion and metastasis, drug resistance, as well as cancer diagnosis, treatment, and prognosis. Nevertheless, its roles in human cancer are still ambiguous, and its mechanisms are sophisticated as well, referring to a variety of targets and signal pathways, such as STAT5B, KRAS, MAPK/ERK signal pathway, Notch pathway, etc. Herein, we review the crucial roles of miR-134 in scores of human cancers via analyzing latest investigations, which might provide evidence for cancer diagnose, treatment, prognosis, or further investigations.

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