期刊
BEST PRACTICE & RESEARCH-CLINICAL ANAESTHESIOLOGY
卷 30, 期 3, 页码 257-269出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bpa.2016.07.006
关键词
aortic cross-clamping; ischemia-reperfusion injury; blood shift; postconditioning
During open aortic surgery, interrupting the blood flow through the aorta by applying a cross-clamp is often a key step to allow for surgical repair. As a consequence, ischemia is induced in parts of the body distal to the clamp site. This significant alteration in the blood flow is almost always associated with hemodynamic changes. Upon release of the cross-clamp, the blood flow is restored, triggering an ischemia-reperfusion response, leading to many pathophysiological processes such as inflammation, humoral changes, and metabolite circulation that could lead to injury in many organ systems and may significantly influence the postoperative outcome. It is therefore important to understand these processes and how they can be treated in order to allow for safe surgical aortic repairs while ensuring the best possible outcomes. (C) 2016 Elsevier Ltd. All rights reserved.
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