期刊
JOURNAL OF HUNTINGTONS DISEASE
卷 5, 期 4, 页码 333-342出版社
IOS PRESS
DOI: 10.3233/JHD-160200
关键词
Huntington's disease; cholinergic; acetylcholine; choline acetyltransferase; cholinergic receptors; cholinergic drugs
In this review, we outline the role of the cholinergic system in Huntington's disease, and briefly describe the dysfunction of cholinergic transmission, cholinergic neurons, cholinergic receptors and cholinergic survival factors observed in post-mortem human brains and animal models of Huntington's disease. We postulate how the dysfunctional cholinergic system can be targeted to develop novel therapies for Huntington's disease, and discuss the beneficial effects of cholinergic therapies in pre-clinical and clinical studies.
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