期刊
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
卷 -, 期 127, 页码 -出版社
JOURNAL OF VISUALIZED EXPERIMENTS
DOI: 10.3791/55987
关键词
Immunology; Issue 127; Formaldehyde; exposure; air pollutant; atopic dermatitis; capsaicin; animal model
资金
- National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [NRF-2014M3C8A5030612]
- Jang Hi Joo Yeu Sa Memorial Fund
Atopic dermatitis is chronically relapsing pruritic eczema and prevails around the world especially in developed countries. Complex interactions between genetic and environmental factors are known to play an important role in the pathophysiology of atopic dermatitis. However, we still lack a detailed picture of the pathogenesis of this disease. Thus, it is of importance to develop appropriate animal models for elucidating the progression of atopic dermatitis. Moreover, investigating the effect of environmental factors such as air pollutants on atopic dermatitis expands understanding of the disease. Here, we describe a method for inducing atopic dermatitis in rats with neonatal capsaicin treatment and a protocol for exposure of a constant concentration of formaldehyde to rats to reveal effects on the development of atopic dermatitis in infantile and adolescent periods. These protocols have been successfully applied to several experiments and can be used for other substances.
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