期刊
JOURNAL OF THORACIC DISEASE
卷 9, 期 1, 页码 E32-E43出版社
AME PUBL CO
DOI: 10.21037/jtd.2017.01.05
关键词
Allergic asthma; reactive oxygen species (ROS); antioxidants
资金
- Central South University Innovation Foundation for Postgraduates [2015zzts114]
- Scientific Research Foundation of Health and Family Planning Commission of Hunan Province [132015-012]
- National Key Scientific & Technology Support Program: Collaborative Innovation of Clinical Research for Chronic Obstructive Pulmonary Disease and Lung Cancer [2013BAI09B09]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R21AI109062, R21AI121768] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES021739] Funding Source: NIH RePORTER
Allergic asthma has a global prevalence, morbidity, and mortality. Many environmental factors, such as pollutants and allergens, are highly relevant to allergic asthma. The most important pathological symptom of allergic asthma is airway inflammation. Accordingly, the unique role of reactive oxygen species (ROS) had been identified as a main reason for this respiratory inflammation. Many studies have shown that inhalation of different allergens can promote ROS generation. Recent studies have demonstrated that several pro-inflammatory mediators are responsible for the development of allergic asthma. Among these mediators, endogenous or exogenous ROS are responsible for the airway inflammation of allergic asthma. Furthermore, several inflammatory cells induce ROS and allergic asthma development. Airway inflammation, airway hyper-responsiveness, tissue injury, and remodeling can be induced by excessive ROS production in animal models. Based on investigations of allergic asthma and ROS formation mechanisms, we have identified several novel anti-inflammatory therapeutic treatments. This review describes the recent data linking ROS to the pathogenesis of allergic asthma.
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