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Primary pulmonary malignant fibrous histiocytoma: case report and literature review

期刊

JOURNAL OF THORACIC DISEASE
卷 9, 期 8, 页码 E702-+

出版社

PIONEER BIOSCIENCE PUBL CO
DOI: 10.21037/jtd.2017.07.59

关键词

Malignant fibrous histiocytoma (MFH); sarcoma; surgery; sequencing

资金

  1. National Natural Science Foundation of China [81301812, 81172233]
  2. Specialized Research Fund for the Doctoral Program of Higher Education [20131202120004]
  3. Science & Technology Foundation for Selected overseas Chinese scholar Ministry of personnel of China
  4. Science & Technology Foundation for Selected overseas Chinese scholar Bureau of personnel of China Tianjin
  5. Tianjin Key Project of Natural Science Foundation [17JCZDJC36200]
  6. Tianjin Educational Committee Foundation [20120117]
  7. Tianjin Medical University General Hospital Young Incubation Foundation [ZYYFY2015015]

向作者/读者索取更多资源

Malignant fibrous histiocytoma (MFH) is an aggressive soft tissue sarcoma known to occur in various organs. Primary MFH arising in the lung is quite rare. Herein we report a case of a 61-year-old male with primary pulmonary MFH and explore the underlying molecular mechanisms by next-generation sequencing (NGS). Five gene mutations in TSC2, ARID1B, CDK8, KDM5C and CASP8 were detected, and the mTOR inhibitor might be an effective treatment for this patient. In addition, we reviewed the scientific literature of approximately 23 primary pulmonary MFH case reports since 1990 and summarized the clinical features and prognosis of this rare pulmonary malignant tumor.

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