期刊
JOURNAL OF CO2 UTILIZATION
卷 22, 期 -, 页码 262-269出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jcou.2017.10.006
关键词
beta-glucan; Acetylsalicylic acid; Aerogel; Rheology; Supercritical drying; Supercritical impregnation
资金
- Ministerio de Economia y Competitividad (MINECO) from Fundacion General of the University of Valladolid [CTQ2013-44143-R, PIP 063/147181]
- Ministerio de Educacion, Ciencia y Deporte (MECD)
- MINECO
- UVa [JCI-2012-14992]
- European Union Seventh Framework Programme [REGPOT-CT2012-316331-POLARIS]
- project Novel smart and biomimetic materials for innovative regenerative medicine approaches [RL1 - ABMR - NORTE-01-0124-FEDER-000016]
- North Portugal Regional Operational Programme (ON.2-O Novo Norte), under National Strategic Reference Framework (NSRF), through European Regional Development Fund (ERDF)
Polysaccharide aerogels are a good alternative as carriers for drug delivery, since they allow high loading of the active compounds in matrices that are non-toxic, biocompatible and from a renewable feedstock. In this work, barley and yeast beta-glucans aerogels were produced by gelation in aqueous solution, followed by solvent exchange and drying with supercritical CO2. First, viscoelastic properties and melting profile of the hydrogels were determined. Then, the obtained aerogels were analyzed regarding morphology, mechanical properties and behavior in physiological fluid. Both in the hydrogels and in the aerogels, big differences were observed between barley and yeast beta-glucans due to their different chain structure and gelation behavior. Finally, impregnation of acetylsalicylic acid was performed at the same time as the drying of the alcogels with supercritical CO2. The release profile of the drug in PBS was analyzed in order to determine the mechanism governing the release from the beta-glucan matrix.
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