期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 17, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/ijms17121997
关键词
p53; I kappa B-alpha; tumor suppressors; functional inactivation
资金
- Italian Ministero della Salute, Giovani Ricercatori-Ricerca Finalizzata [GR-2011-02351167]
TP53 is one of the most frequently-mutated and deleted tumor suppressors in cancer, with a dramatic correlation with dismal prognoses. In addition to genetic inactivation, the p53 protein can be functionally inactivated in cancer, through post-transductional modifications, changes in cellular compartmentalization, and interactions with other proteins. Here, we review the mechanisms of p53 functional inactivation, with a particular emphasis on the interaction between p53 and I kappa B-alpha, he NFKBIA gene product.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据