Model-Derived Markers of Autonomic Cardiovascular Dysfunction in Sleep-Disordered Breathing

Evidence indicates that sleep-disordered breathing leads to elevated sympathetic tone and impaired vagal activity, promoting hypertension and cardiometabolic disease. Low-cost but accurate monitoring of autonomic function is useful for the aggressive management of sleep apnea. This article reviews the development and application of multivariate dynamic biophysical models that enable the causal dependencies among respiration, blood pressure, heart rate variability, and peripheral vascular resistance to be quantified. The markers derived from these models can be used in conjunction with heart rate variability to increase the sensitivity with which abnormalities in autonomic cardiovascular control are detected in subjects with sleep-disordered breathing.